Guiding endosomal maturation

Cell. 2010 Apr 30;141(3):404-6. doi: 10.1016/j.cell.2010.04.013.


In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).

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