Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jul 6;130(1):183-6.
doi: 10.1016/j.jep.2010.04.024. Epub 2010 May 6.

Immunosuppressive Activity of Ethanolic Extract of Seeds of Moringa Oleifera Lam. In Experimental Immune Inflammation

Affiliations

Immunosuppressive Activity of Ethanolic Extract of Seeds of Moringa Oleifera Lam. In Experimental Immune Inflammation

Shailaja G Mahajan et al. J Ethnopharmacol. .

Abstract

Ethnopharmacological relevance: Traditionally, the plant Moringa oleifera Lam. (Moringaceae) is used for the treatment of ascites and rheumatism, while the dried seeds of the plant are used as an 'anti-allergic' agent.

Aim of the study: The aim of the study was to assess the efficacy of ethanolic extract of seeds from Moringa oleifera Lam. in experimental immune inflammation.

Materials and methods: Circulatory and splenic leukocyte counts, delayed-type hypersensitivity reactions and humoral antibody responses were measured in mice using SRBC as the antigen. In addition, macrophage phagocytosis was measured by the carbon clearance test.

Results: The extract dose-dependently (50, 100 and 200mg/kg) inhibited spleen weight as well as circulatory leukocyte and splenocyte counts. The delayed-type hypersensitivity reaction was significantly inhibited (P<0.01) by decreasing the mean foot pad thickness at 48 h. The production of the humoral antibody titer was significantly ameliorated at a dose of 100 and 200mg/kg (P<0.05 and P<0.01, respectively). Furthermore, the extract caused a down-regulation of macrophage phagocytosis due to carbon particles.

Conclusion: Taken together, the above findings suggest that the seeds of Moringa oleifera have immunosuppressive activity.

Similar articles

See all similar articles

Cited by 11 articles

See all "Cited by" articles

LinkOut - more resources

Feedback