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Review
, 7 (3), 300-4

The Ups and Downs of miR-205: Identifying the Roles of miR-205 in Mammary Gland Development and Breast Cancer

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Review

The Ups and Downs of miR-205: Identifying the Roles of miR-205 in Mammary Gland Development and Breast Cancer

Stephanie B Greene et al. RNA Biol.

Abstract

Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.

Figures

Figure 1
Figure 1
miR-205 expression in mammary gland cells. Cells comprising the mammary gland can by identified by their cell surface marker profiles. High miR-205 expression is found in the stem cell-enriched populations: CD24+/loSca-1, CD29hiCD24+ and CD49fhiCD24med (also referred to as the MRU population) and the myoepithelial cell populations: CD24+/loSca-1, CD29hiCD24+ and CD49floCD24lo. Low miR-205 expression is in the ductal (CD24+/hiSca1+, CD29loCD24+ and CD49f+CD24+) and alveolar (CD24+/hiSca1 and CD29loCD24+) populations.
Figure 2
Figure 2
miR-205 in epithelial cells. Model of context-specific effects of miR-205 on cellular phenotype. On the left side, miR-205 can act as an oncogene and/or affect cell fate in mammary stem cells and keratinocytes by targeting tumor-suppressors like PTEN and SHIP2, respectively. In other cellular contexts, miR-205 can act as a tumor-suppressor and/or affect epithelial characteristics. Other targets of miR-205 include the oncogenes HER3, E2F1, E2F5 and PKCε, the pro-metastatic genes Zeb1 and Zeb2, and the angiogenic factor VEGFA (right side). There are also many unknown targets of miR-205 that may regulate proliferation, cell size and progenitor cell expansion.

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