Random lasing in bone tissue

Opt Lett. 2010 May 1;35(9):1425-7. doi: 10.1364/OL.35.001425.


Owing to the low-loss and high refractive index variations derived from the basic building block of bone structure, we, for the first time to our knowledge, demonstrate coherent random lasing action originated from the bone structure infiltrated with laser dye, revealing that bone tissue is an ideal biological material for random lasing. Our numerical simulation shows that random lasers are extremely sensitive to subtle structural changes even at nanoscales and can potentially be an excellent tool for probing nanoscale structural alterations in real time as a novel spectroscopic modality.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone and Bones / radiation effects*
  • Cattle
  • Coloring Agents
  • Feasibility Studies
  • Lasers*


  • Coloring Agents