H1/H1 genotype influences symptom severity in corticobasal syndrome

Mov Disord. 2010 Apr 30;25(6):760-3. doi: 10.1002/mds.22804.


We evaluated 38 consecutive patients with corticobasal syndrome to determine if inheritance of the H1/H1 genotype influences age at onset and disease severity and if Apolipoprotein E e4 increases the risk of cognitive disturbances. Inheritance of the H1/H1 genotype was associated with severity of motor function, but did not affect age at onset or cognition. There was a trend toward shorter survival in the H1/H1 group, but this study was underpowered to test influence on survival, even though it served to estimate the sample size for future studies. ApoE inheritance did not influence cognition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Apolipoprotein E4 / genetics
  • Case-Control Studies
  • Dystonia / complications
  • Dystonia / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Mental Status Schedule
  • Middle Aged
  • Psychomotor Disorders / complications
  • Psychomotor Disorders / genetics*
  • Severity of Illness Index
  • Syndrome
  • tau Proteins / genetics*


  • Apolipoprotein E4
  • tau Proteins