The effects of IL2Rgamma knockout on depression and contextual memory

Behav Brain Res. 2010 Dec 1;213(2):319-22. doi: 10.1016/j.bbr.2010.04.046. Epub 2010 May 12.


Interleukin (IL)-2Rgamma shows robust upregulation in neuroinflammatory states associated with clinical depression. We tested the hypothesis that mice lacking IL2Rgamma would have decreased depressive-like behavior. Contrary to this expectation, these knockout mice showed increased immobility in both the Porsolt forced swimming and Nomura water wheel tests. By comparison, the auditory fear conditioning test showed increased retention of contextual freezing. Thus, intact IL2Rgamma combats depressive-like behavior.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Conditioning, Psychological / physiology
  • Depression / genetics*
  • Disease Models, Animal
  • Fear / physiology
  • Female
  • Freezing Reaction, Cataleptic
  • Immobility Response, Tonic / physiology
  • Interleukin Receptor Common gamma Subunit / genetics*
  • Male
  • Memory / physiology*
  • Mice
  • Mice, Knockout
  • Sex Characteristics


  • Il2rg protein, mouse
  • Interleukin Receptor Common gamma Subunit