Achievement of fertility in an infertile man with resistant macroprolactinoma using high-dose bromocriptine and a combination of human chorionic gonadotropin and an aromatase inhibitor

Endocr Pract. Jul-Aug 2010;16(4):669-72. doi: 10.4158/EP10026.CR.


Objective: To describe the achievement of fertility in an infertile man with a resistant macroprolactinoma by using high-dose bromocriptine and a combination of human chorionic gonadotropin (hCG) and an aromatase inhibitor.

Methods: We present historical features and results of clinical, laboratory, and imaging evaluation in a man with secondary infertility attributable to a resistant macroprolactinoma.

Results: We report a case of macroprolactinoma in a 36-year-old infertile man who failed to attain a normal serum testosterone level and fertility with use of either bromocriptine or cabergoline treatment. Testosterone replacement or hCG therapy in this patient resulted in an increase in serum prolactin levels, which declined after discontinuation of this therapy. The combination of high doses of bromocriptine, hCG, and an aromatase inhibitor facilitated near-normalization of serum prolactin levels, shrinkage of the macroprolactinoma, recovery of serum testosterone levels, sexual function, and sperm count, and achievement of fertility.

Conclusion: An aromatase inhibitor may facilitate successful testosterone replacement therapy in male patients with prolactinoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aromatase Inhibitors / therapeutic use*
  • Bromocriptine / administration & dosage
  • Bromocriptine / therapeutic use*
  • Chorionic Gonadotropin / therapeutic use*
  • Dopamine Agonists / administration & dosage
  • Dopamine Agonists / therapeutic use*
  • Drug Resistance, Neoplasm
  • Drug Therapy, Combination
  • Galactorrhea / etiology
  • Hormone Replacement Therapy
  • Humans
  • Infertility, Male / blood
  • Infertility, Male / drug therapy*
  • Infertility, Male / etiology
  • Male
  • Pituitary Neoplasms / blood
  • Pituitary Neoplasms / drug therapy
  • Pituitary Neoplasms / physiopathology*
  • Prolactinoma / blood
  • Prolactinoma / drug therapy
  • Prolactinoma / physiopathology*
  • Testosterone / blood
  • Testosterone / deficiency
  • Tumor Burden / drug effects


  • Aromatase Inhibitors
  • Chorionic Gonadotropin
  • Dopamine Agonists
  • Bromocriptine
  • Testosterone