Abstract
We report here the case of a child with a known muscular abnormality and susceptibility to malignant hyperthermia who abruptly died after receiving a therapeutic dose of ondansetron. Also, we discuss the pharmacodynamic relationship of ondansetron to malignant hyperthermia in a susceptible host.
MeSH terms
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Antiemetics / adverse effects*
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Antiemetics / pharmacology
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Antiemetics / therapeutic use
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Child, Preschool
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Diseases in Twins / genetics
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Fatal Outcome
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Genetic Predisposition to Disease*
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Humans
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Male
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Malignant Hyperthermia / etiology*
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Malignant Hyperthermia / genetics
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Myopathies, Structural, Congenital / genetics*
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Ondansetron / adverse effects*
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Ondansetron / pharmacology
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Ondansetron / therapeutic use
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Ryanodine Receptor Calcium Release Channel / genetics*
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Triplets
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Twins, Monozygotic
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Vomiting / drug therapy
Substances
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Antiemetics
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Ryanodine Receptor Calcium Release Channel
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Ondansetron