Application of the GRAPPA psoriatic arthritis treatment recommendations in clinical practice

Curr Rheumatol Rep. 2010 Aug;12(4):264-71. doi: 10.1007/s11926-010-0109-y.


Psoriatic disease presents with a complex array of clinical features, including peripheral synovitis and skin psoriasis, but there is also variable involvement of the nail, dactylitis, enthesitis, and spinal disease. Composite assessment of disease activity and response taking into account the impact of the disease as a whole on an individual's health and quality of life is of vital importance. Following an extensive literature review, discussions, and consensus, the Group for Research in Psoriasis and Psoriatic Arthritis (GRAPPA) published guidelines to help clinicians make treatment decisions. The utility of these guidelines in routine clinical practice is further enhanced by incorporating them into a Composite Psoriatic Disease Activity Index (CPDAI). The potential application of the CPDAI in typical psoriatic disease patients is presented and discussed. Validation and possible modification of a composite disease activity and responder index is currently being undertaken by GRAPPA.

Publication types

  • Review

MeSH terms

  • Arthritis, Psoriatic / therapy*
  • Clinical Protocols
  • Humans
  • Severity of Illness Index