Direct sequencing of the human microbiome readily reveals community differences

Genome Biol. 2010;11(5):210. doi: 10.1186/gb-2010-11-5-210. Epub 2010 May 5.


Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / genetics*
  • Base Sequence
  • Disease
  • Ecosystem
  • Humans
  • Metagenome / genetics*
  • Molecular Sequence Data
  • Sequence Analysis, DNA / methods*