Mechanisms of Inflammation in Gout

Arthritis Res Ther. 2010;12(2):206. doi: 10.1186/ar2952. Epub 2010 Apr 26.

Abstract

An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Animals
  • Carrier Proteins / immunology
  • Chemotaxis, Leukocyte / immunology
  • Crystallization
  • Disease Models, Animal
  • Gout / immunology*
  • Gout / pathology
  • Humans
  • Inflammation / immunology*
  • Inflammation / pathology
  • Interleukin-1beta / metabolism*
  • Leukocytes / immunology*
  • Leukocytes / pathology
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Phagocytosis
  • Uric Acid / immunology*

Substances

  • Carrier Proteins
  • Interleukin-1beta
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Uric Acid