Condensin and cohesin complexity: the expanding repertoire of functions

Nat Rev Genet. 2010 Jun;11(6):391-404. doi: 10.1038/nrg2794. Epub 2010 May 5.

Abstract

Condensin and cohesin complexes act in diverse nuclear processes in addition to their widely known roles in chromosome compaction and sister chromatid cohesion. Recent work has elucidated the contribution of condensin and cohesin to interphase genome organization, control of gene expression, metazoan development and meiosis. Despite these wide-ranging functions, several themes have come to light: both complexes establish higher-order chromosome structure by inhibiting or promoting interactions between distant genomic regions, both complexes influence the chromosomal association of other proteins, and both complexes achieve functional specialization by swapping homologous subunits. Emerging data are expanding the range of processes in which condensin and cohesin are known to participate and are enhancing our knowledge of how chromosome architecture is regulated to influence numerous cellular functions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Adenosine Triphosphatases / physiology*
  • Animals
  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology*
  • Chromatin Assembly and Disassembly / physiology
  • Chromosomal Proteins, Non-Histone / metabolism
  • Chromosomal Proteins, Non-Histone / physiology*
  • DNA-Binding Proteins / metabolism
  • DNA-Binding Proteins / physiology*
  • Gene Expression Regulation / physiology
  • Genome / physiology
  • Humans
  • Meiosis / genetics
  • Meiosis / physiology
  • Models, Biological
  • Multiprotein Complexes / metabolism
  • Multiprotein Complexes / physiology*

Substances

  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Multiprotein Complexes
  • cohesins
  • condensin complexes
  • Adenosine Triphosphatases