Intestinal ecology in the metabolic syndrome

Michele Petruzzelli; Antonio Moschetta

doi:10.1016/j.cmet.2010.04.012

Intestinal ecology in the metabolic syndrome

Cell Metab. 2010 May 5;11(5):345-6. doi: 10.1016/j.cmet.2010.04.012.

Authors

Michele Petruzzelli¹, Antonio Moschetta

Affiliation

¹ Clinica Medica Augusto Murri, University of Bari and Department of Translational Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro (CH), Italy.

PMID: 20444415
DOI: 10.1016/j.cmet.2010.04.012

Abstract

Nutritional and genetic factors alter the intestinal microflora, predisposing individuals toward metabolic syndrome. Gewirtz and coworkers (Vijay-Kumar et al., 2010), employing Toll-like receptor 5 null mice, present evidence for a direct relationship between malfunction of the innate immune system, changes in gut microbiota composition, and development of metabolic syndrome.

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