[Secondary osteoporosis UPDATE. Osteomalacia]

Clin Calcium. 2010 May;20(5):684-8.
[Article in Japanese]


Vitamin D related osteomalacia consisted of vitamin D deficient and resistant forms. Vitamin D deficiency was frequently suggested as a complication of osteoporosis. Vitamin D was synthesized in the skin from pro vitamin D by sunlight. And the elderly residents in the nursing home who do not want to come outside frequently are at high risk. Also, the people taking anti-convulsant are the case, because the medications promoted the catabolism of vitamin D through the induction of an enzyme linked to cytochrome P450. Since the effect of bisphosphonate was reported to be decreased in vitamin D deficiency, we have to keep in mind for adding native or active vitamin D for the target people of osteoporosis.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Anticonvulsants / adverse effects
  • Cytochrome P-450 Enzyme System
  • Diphosphonates / administration & dosage
  • Humans
  • Metabolism
  • Osteomalacia / complications
  • Osteomalacia / drug therapy
  • Osteomalacia / etiology*
  • Osteoporosis / complications
  • Osteoporosis / drug therapy
  • Risk
  • Vitamin D / administration & dosage
  • Vitamin D / metabolism
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / drug therapy


  • Anticonvulsants
  • Diphosphonates
  • Vitamin D
  • Cytochrome P-450 Enzyme System