Chronic recurrent multifocal osteomyelitis as the first presentation of acute lymphoblastic leukemia in a 2-year-old boy

J Pediatr Hematol Oncol. 2010 May;32(4):e151-2. doi: 10.1097/MPH.0b013e3181d1ec16.


We present herein a 2-year-old boy who suffered from chronic recurrent multifocal osteomyelitis for 6 months and was later diagnosed as acute lymphoblastic leukemia. In view of the rarity of bilateral symmetric and multifocal lesions in osteomyelitis in children, we suggest that leukemia should be investigated with bone marrow aspiration in such patients, even if complete blood count parameters are normal, and there is no hepatosplenomegaly.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Chronic Disease
  • Diagnosis, Differential
  • Humans
  • Male
  • Osteomyelitis / diagnosis*
  • Osteomyelitis / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Prognosis
  • Recurrence