The intestinal microbiota in inflammatory bowel diseases: time to connect with the host

Curr Opin Gastroenterol. 2010 Jul;26(4):327-31. doi: 10.1097/MOG.0b013e328339536b.


Purpose of review: The aim of this review is to report recent findings regarding the role of the gut microbiota in inflammatory bowel disease pathogenesis.

Recent findings: After a description of the current knowledge on inflammatory bowel diseases-associated dysbiosis, we will focus on the recent functional studies that analyzed the cross relationship between the gut microbiota and the host.

Summary: Recently published studies have provided an insight into the altered dialog between the intestinal microbiota and the host leading to gut inflammation. Further investigation will allow identifying new therapeutic targets either in the microbiota or the host.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Physiological Phenomena
  • Host-Pathogen Interactions
  • Humans
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / microbiology*
  • Intestines / immunology
  • Intestines / microbiology*
  • Mice
  • T-Lymphocytes / immunology