Abstract
Use of a bis-dithiane deprotection-tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.
MeSH terms
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Alkylation
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Antimitotic Agents / chemical synthesis*
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Antimitotic Agents / chemistry
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Macrolides / chemical synthesis*
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Macrolides / chemistry
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Protein Phosphatase 2 / antagonists & inhibitors
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Protein Phosphatase 2 / metabolism
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Quinolizines / chemistry*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Sulfur Compounds / chemistry*
Substances
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Antimitotic Agents
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Macrolides
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Quinolizines
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Spiro Compounds
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Sulfur Compounds
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dithiane
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spirastrellolide B
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Protein Phosphatase 2