Diffusion tensor imaging of the cingulum bundle in children after traumatic brain injury

Dev Neuropsychol. 2010;35(3):333-51. doi: 10.1080/87565641003696940.


Structural damage to the prefrontal-cingulate network has been implicated in cognitive and neurobehavioral deficits associated with traumatic brain injury (TBI). Forty-six children who had sustained moderate-to-severe TBI and 43 children with extracranial injury were imaged using diffusion tensor imaging (DTI). Decreased fractional anisotropy (FA) and increased apparent diffusion coefficient (ADC) values were found in the cingulum bundles bilaterally in the TBI group. Cingulum ADC was related to frontal lesion volume, injury severity, and injury mechanism. Finally, cingulum DTI parameters were related to cognitive control measures. DTI detects TBI-related injury to the cingulum, which may facilitate advances in assessment and treatment.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Anisotropy
  • Brain Injuries / complications
  • Brain Injuries / pathology*
  • Brain Mapping
  • Child
  • Cognition Disorders / etiology
  • Diffusion Tensor Imaging / methods*
  • Female
  • Functional Laterality
  • Gyrus Cinguli / pathology*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods
  • Male
  • Nerve Fibers / pathology*
  • Neuropsychological Tests
  • Recognition, Psychology / physiology
  • Reproducibility of Results
  • Socioeconomic Factors
  • Statistics as Topic / methods