The goal of treatment in arteriosclerosis obliterans (ASO) is to aggressively treat atherosclerotic risk factors to reduce future cardiovascular events as well as to improve symptoms of claudication and prevent limb amputation. Patients with ASO have an increased risk of cardiovascular events such as myocardial infarction and stroke in addition to significant impairment in their quality of life and physical function. Strategies for management of ASO include conservative treatment with risk factor modification, smoking cessation, exercise, pharmacologic therapy, balloon angioplasty and stenting of vessels, or bypass surgery, and therapeutic angiogenesis. In addition, the prevention and treatment for cardiovascular events such as myocardial infarction and stroke are important, too.