Abstract
Pd(II)-catalyzed ortho C-H acetoxylation of triflate protected phenethyl- and phenpropylamines has been achieved with tert-butyl peroxyacetate as the stoichiometric oxidant and either DMF or CH(3)CN as the promoter. The reaction was found to tolerate a large variety of functional groups and could be combined with subsequent intramolecular amination to afford functionalized indoline derivatives.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Amination
-
Catalysis
-
Ephedrine / analogs & derivatives*
-
Ephedrine / chemistry*
-
Indoles / chemical synthesis*
-
Indoles / chemistry
-
Molecular Structure
-
Oxidation-Reduction
-
Palladium / chemistry*
-
Phenylalanine / analogs & derivatives*
-
Phenylalanine / chemistry*
Substances
-
Indoles
-
Phenylalanine
-
Palladium
-
indoline
-
Ephedrine