Immunological and regenerative properties of cord blood stem cells

Clin Immunol. 2010 Sep;136(3):309-22. doi: 10.1016/j.clim.2010.04.010. Epub 2010 May 5.

Abstract

Cord blood stem cells (CB-SCs) have shown impressive immunological and regenerative capabilities. In this review, we intend to review the state-of-the-art knowledge on CB-SCs characteristics and function as well as immunological and regenerative properties. We report an itemized classification of CB-SCs populations, which is important to better understand which tissues can be replaced using CB-SCs and how the generation of induced pluripotent stem cells from CB-SCs is changing the field. Furthermore, we will discuss new findings on the immunosuppressive capability of CB-SCs in autoimmune disease (e.g., type 1 diabetes). Our review will demonstrate how CB-SCs could become a powerful tool not only for regenerative medicine but for autoimmune and inflammatory diseases as well.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / therapy
  • Clinical Trials as Topic
  • Cord Blood Stem Cell Transplantation
  • Endocrine System Diseases / therapy
  • Fetal Blood / cytology*
  • Fetal Blood / immunology
  • Fetal Blood / physiology
  • Hematologic Neoplasms / therapy
  • Humans
  • Immunosuppression
  • In Vitro Techniques
  • Metabolism, Inborn Errors / therapy
  • Nervous System Diseases / therapy
  • Regeneration / physiology*
  • Stem Cells / cytology
  • Stem Cells / immunology*
  • Stem Cells / physiology*
  • Transplantation, Autologous
  • Transplantation, Homologous