Gastric acid secretion and parietal cell mass: effect of sex hormones

Gastroenterology. 1991 Jul;101(1):66-9. doi: 10.1016/0016-5085(91)90460-3.

Abstract

The role of sex hormones on parietal cell function and number was studied in the rat. Ovariectomy significantly increased parietal cell mass (from 18.26 +/- 0.16 x 10(6) to 24.14 +/- 0.89 x 10(6] as well as basal acid secretion (from 3.49 +/- 0.06 to 3.63 +/- 0.05 mu Eq/10 min). Castration decreased the number of parietal cells in the gastric mucosa of male rats from 25.57 +/- 0.18 x 10(6) to 18.65 +/- 0.12 x 10(6) and basal acid secretion (from 3.99 +/- 0.03 to 3.50 +/- 0.06 mu Eq/10 min). The results suggest that male and female sex hormones regulate basal acid secretion via their effects on the parietal cell.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Count / drug effects*
  • Female
  • Gastric Acid / metabolism*
  • Gonadal Steroid Hormones / physiology*
  • Male
  • Orchiectomy
  • Organ Size
  • Ovariectomy
  • Parietal Cells, Gastric / drug effects*
  • Parietal Cells, Gastric / physiology
  • Rats
  • Rats, Inbred Strains
  • Stomach / anatomy & histology

Substances

  • Gonadal Steroid Hormones