Japanese Alzheimer's Disease Neuroimaging Initiative: present status and future

Alzheimers Dement. 2010 May;6(3):297-9. doi: 10.1016/j.jalz.2010.03.011.


Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) was launched in 2008, aiming at conducting a longitudinal workup of a standardized neuroimaging, biomarker and clinico-psychological surveys. The research protocol was designed to maximize compatibility with that of US-ADNI, including structural magnetic resonance imaging analysis for the evaluation of brain atrophy, fluorodeoxyglucose and amyloid positron emission tomography, cerebrospinal fluid sampling, APOE genotyping, together with a set of clinical and psychometric tests that were prepared to achieve the highest compatibility to those used in the United States. Japanese ADNI has recruited approximately 357 participants (142 amnestic mild cognitive impairment, approximately 134 normal aged and 72 mild Alzheimer's disease (AD), as of April 15, 2010). World-wide ADNI activities will establish the rigorous quantitative descriptions of the natural course of AD in its very early stages. The data, as well as the methodologies and infrastructures, will facilitate the clinical trials of disease-modifying therapies for AD using surrogate biomarkers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / epidemiology
  • Apolipoprotein E4 / genetics
  • Diagnostic Imaging* / trends
  • Disease Progression
  • Female
  • Health Planning Organizations / organization & administration
  • Health Planning Organizations / statistics & numerical data
  • Health Planning Organizations / trends
  • Humans
  • Japan / epidemiology
  • Male
  • Neuropsychological Tests
  • Psychometrics


  • Apolipoprotein E4