Meta-analysis of rates of drop-out from psychosocial treatment among persons with schizophrenia spectrum disorder

Schizophr Res. 2010 Aug;121(1-3):266-70. doi: 10.1016/j.schres.2010.04.003. Epub 2010 May 8.


Non-compliance with pharmacotherapy among persons suffering from schizophrenia disorders stands at an average rate of 42% and is the subject of numerous studies. However, no studies to date have addressed the specific question of non-compliance with psychosocial treatment. The present study therefore aimed to determine the rate of drop-out from psychosocial treatment and to assess the influence of factors on this rate.

Method: A meta-analysis was conducted based on 74 studies of randomized clinical trials on psychosocial treatment among persons suffering from schizophrenia spectrum disorder.

Results: A drop-out rate of 13% was obtained. Age, gender, duration of illness, duration of treatment, treatment setting and study quality affected drop-out rates.

Conclusion: The 13% rate of drop-out from psychosocial treatment is markedly lower than the drop-out rate from pharmacotherapy studies. This finding supports the feasibility of evidence-based psychosocial treatment - which has, moreover, clearly been shown to be clinically effective - as part of a complete care program for schizophrenia.

Publication types

  • Meta-Analysis

MeSH terms

  • Databases, Bibliographic / statistics & numerical data
  • Female
  • Humans
  • Male
  • Patient Compliance / psychology
  • Patient Compliance / statistics & numerical data
  • Patient Dropouts / statistics & numerical data
  • Psychiatric Status Rating Scales
  • Psychotherapy / methods*
  • Randomized Controlled Trials as Topic
  • Schizophrenia / therapy*
  • Schizophrenic Psychology*
  • Treatment Outcome