Yorkie: the final destination of Hippo signaling

Trends Cell Biol. 2010 Jul;20(7):410-7. doi: 10.1016/j.tcb.2010.04.005. Epub 2010 May 7.

Abstract

The Hippo signaling pathway is a key regulator of growth during animal development, whereas loss of normal Hippo pathway activity is associated with a wide range of cancers. Hippo signaling represses growth by inhibiting the activity of a transcriptional co-activator protein, known as Yorkie in Drosophila and Yap in vertebrates. In the 5 years since the first report linking Yorkie to Hippo signaling, intense interest in this pathway has led to rapid increases in our understanding of the action and regulation of Yorkie/Yap, which we review here. These studies have also emphasized the complexity of Yorkie/Yap regulation, including multiple, distinct mechanisms for repressing its transcriptional activity, and multiple DNA-binding partner proteins that can direct Yorkie to distinct downstream target genes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila Proteins / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Nuclear Proteins / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*
  • Trans-Activators / metabolism*

Substances

  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • Trans-Activators
  • Yki protein, Drosophila
  • Protein-Serine-Threonine Kinases
  • hpo protein, Drosophila