This study tested the efficacy of the Information-Motivation-Behavioral (IMB) skills model-based intervention to promote adherence among patients undergoing Coronary Artery Bypass Grafting (CABG) surgery, and evaluated the relationship of psychological variables with adherence. A total of 152 CABG patients were randomly assigned to either an intervention group or to a standard care control group. Participants completed pretest measures and were reassessed one and three months later. Findings revealed that the intervention group was significantly more adherent, which showed support for the effectiveness of the IMB-based intervention. Furthermore, psychological factors played an important role in patient adherence.