Synthesis of cyano-2,3-dihydropyrrolo[1,2-f]phenanthridine derivatives via a domino-Knoevenagel-cyclization

Mol Divers. 2011 Feb;15(1):197-201. doi: 10.1007/s11030-010-9254-5. Epub 2010 May 8.

Abstract

In a new multicomponent reaction phenanthridine reacts with isocyanides and malonitrile in the presence of benzaldehyde derivatives to produce 2-aryl-3-(alkyl- or arylimino)-2,3-dihydropyrrolo[1,2-f]phenanthridine-1,1(12b H)-dicarbonitrile in a simple, mild, and efficient protocol in excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzaldehydes / chemistry
  • Cyclization
  • Nitriles / chemistry
  • Phenanthridines / chemical synthesis*
  • Phenanthridines / chemistry*
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry*
  • Temperature

Substances

  • Benzaldehydes
  • Nitriles
  • Phenanthridines
  • Pyridines
  • dicyanmethane
  • benzaldehyde