Protective effect of ginger against alcohol-induced renal damage and antioxidant enzymes in male albino rats

Indian J Exp Biol. 2010 Feb;48(2):143-9.


Superoxide dismutase, ascorbic acid, glutathione and uric acid levels were decreased and xanthine oxidase, glutathione-s-transferase activities were increased in alcohol treated (2 g/kg body weight, once daily for 30 days) group. However, treatment with ethanolic extract of ginger (100 mg/kg, 200 mg/kg body weight, po, once daily for 30 days) these parameters came to normalcy showing the antioxidant effect of ginger. The antioxidant compounds of ginger may modulate the oxidative stress parameters. The biochemical findings were supplemented by histopathological examination of the kidney. Severe congestion and degenerative changes in tubules in alcohol treated rats were restored by ginger extract treatment. The results confirm the renal protective effect of ginger in alcohol treated rats.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ethanol / pharmacology*
  • Ethanol / toxicity
  • Ginger / chemistry*
  • Glutathione / metabolism
  • Glutathione Transferase / metabolism
  • Humans
  • Kidney / drug effects*
  • Kidney / metabolism
  • Kidney / pathology*
  • Male
  • Plant Extracts / pharmacology*
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species / metabolism
  • Superoxide Dismutase / metabolism
  • Xanthine Oxidase / metabolism


  • Plant Extracts
  • Reactive Oxygen Species
  • Ethanol
  • Superoxide Dismutase
  • Xanthine Oxidase
  • Glutathione Transferase
  • Glutathione