Surgical treatment of iris and ciliary body melanoma: follow-up of a 25-year series of patients

Acta Ophthalmol. 2012 Mar;90(2):122-6. doi: 10.1111/j.1755-3768.2010.01889.x. Epub 2010 Apr 28.


Purpose: To evaluate outcome of surgical resection of iris and irido-ciliary melanomas.

Method: Retrospective analysis of all cases treated in Denmark 1975-1999 with clinical follow-up in 2002 and death certificate analysis in 2008. A quality of life questionnaire was completed at follow-up.

Results: A total of 53 patients were identified. Of these, 47 were examined at follow-up. Median observation time was 7.15 years (range 0.3-27.4 years). Five patients had died of nonmelanoma causes, and one could not be reached because of immigration. None of the patient had melanoma metastases, and none had died of melanoma-related causes. Only one patient had a local recurrence, which was successfully treated by cryotherapy. The quality of life-related questions demonstrated that most patients (40) suffered from photophobia, and eight patients had changed their driving habits, not driving at night time. However, none had changed job as a consequence of the surgical treatment. Only two patients were emotionally affected by the diagnosis of iris melanoma.

Conclusion: Resection of small iris and irido-ciliary melanomas is a safe and efficient procedure, provided that strict diagnostic and surgical procedures are followed and the preoperative intraocular pressure is normal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Ciliary Body / pathology
  • Ciliary Body / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Intraocular Pressure
  • Iridectomy
  • Iris Neoplasms / mortality
  • Iris Neoplasms / pathology
  • Iris Neoplasms / psychology
  • Iris Neoplasms / surgery*
  • Lasers, Semiconductor / therapeutic use
  • Male
  • Melanoma / mortality
  • Melanoma / pathology
  • Melanoma / psychology
  • Melanoma / surgery*
  • Middle Aged
  • Ophthalmologic Surgical Procedures*
  • Quality of Life / psychology
  • Retrospective Studies
  • Surveys and Questionnaires
  • Survival Rate
  • Suture Techniques
  • Treatment Outcome
  • Young Adult