Regulation of Gene Expression in Peripheral T Cells by Runx Transcription Factors

Adv Immunol. 2009;104:1-23. doi: 10.1016/S0065-2776(08)04001-7. Epub 2009 Dec 1.

Abstract

Members of the Runx family of transcription factors, Runx1-3, are essential regulators of the immune system: a deficiency in one of the members, Runx1, results in complete ablation of hematopoiesis, and all three Runx proteins play important, nonredundant roles in immune system development and function. Here, we review gene regulation by Runx proteins in T lymphocytes, with a focus on their recently emerging roles in the development and function of peripheral CD4+ and CD8+ T lineages.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Core Binding Factor alpha Subunits / immunology*
  • Gene Expression Regulation*
  • Humans
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism

Substances

  • Core Binding Factor alpha Subunits