Next-generation biomarkers for detecting kidney toxicity

Nat Biotechnol. 2010 May;28(5):436-40. doi: 10.1038/nbt0510-436.


There is a paucity of biomarkers that reliably detect nephrotoxicity. The Predictive Safety Testing Consortium (PSTC) faced several challenges in identifying novel safety biomarkers in the renal setting.

MeSH terms

  • Animals
  • Biomarkers, Pharmacological / urine*
  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Kidney Tubules* / drug effects
  • Kidney Tubules* / injuries
  • Toxicity Tests / standards*


  • Biomarkers, Pharmacological