Proc Am Thorac Soc. 2010 May;7(3):169-72. doi: 10.1513/pats.200907-069AL.


Histoplasmosis is the most prevalent endemic fungal infection in North America. The clinical spectrum ranges from asymptomatic, self-limited illness to a life-threatening progressive disseminated disease. Chronic manifestations of healed infection can also be problematic. Clinical presentation depends on the infectious load, underlying immune status, and lung function. The preferred diagnostic methods and treatment options vary with clinical scenario and severity of illness. New diagnostic tools and treatment options are now available in clinical practice. We present an overview of this important endemic mycosis with emphasis on diagnosis and treatment recommendations for the different clinical syndromes of histoplasmosis.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use
  • Bronchial Diseases / microbiology
  • Bronchoalveolar Lavage
  • Disease Progression
  • Histoplasmosis / diagnosis*
  • Histoplasmosis / drug therapy
  • Histoplasmosis / epidemiology
  • Histoplasmosis / therapy
  • Humans
  • Immunocompromised Host
  • Itraconazole / administration & dosage
  • Itraconazole / therapeutic use
  • Lithiasis / microbiology
  • Lung Diseases, Fungal / diagnosis*
  • Lung Diseases, Fungal / drug therapy
  • Lung Diseases, Fungal / epidemiology
  • Lung Diseases, Fungal / therapy
  • Multiple Pulmonary Nodules / microbiology
  • Solitary Pulmonary Nodule / microbiology
  • Treatment Outcome


  • Antifungal Agents
  • Itraconazole