Modification in body weight associated with antiepileptic drugs

Arq Neuropsiquiatr. 2010 Apr;68(2):277-81. doi: 10.1590/s0004-282x2010000200024.

Abstract

Antiepileptic drugs (AED) may cause body weight changes.

Objective: To evaluate the dietary habits and body weight associated with AED in epileptic patients.

Method: Sixty-six patients were subjected to two interviews, and had their weight and body mass index calculated and compared at both times, interval between six to eight months.

Results: It was observed that 59.1% showed weight gain. The patients who had no weight gain had a greater proportion of individuals who engaged in some form of physical activity. However, of the 45 patients who maintained their initial dietary and medication pattern, 75.6% recorded a weight gain. Weight gain was seen in 66.7% of patients on carbamazepine (n=18), 60% on valproate (n=5), 50% on carbamazepine+clobazam treatment (n=14), and 58.3% of patients on other(s) polytherapy (n=12).

Conclusion: The patient should be alerted to possible weight gain, and should be advised about dieting and participating in regular physical activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Body Mass Index
  • Carbamazepine / adverse effects*
  • Carbamazepine / therapeutic use
  • Epilepsy / drug therapy
  • Female
  • Humans
  • Male
  • Valproic Acid / adverse effects*
  • Valproic Acid / therapeutic use
  • Weight Gain / drug effects*

Substances

  • Anticonvulsants
  • Carbamazepine
  • Valproic Acid