DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history

Curr Diab Rep. 2010 Aug;10(4):276-82. doi: 10.1007/s11892-010-0120-8.


The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autonomic Nervous System Diseases / etiology
  • Autonomic Nervous System Diseases / therapy
  • Cardiomyopathies / etiology
  • Cardiomyopathies / therapy
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 1 / metabolism
  • Diabetes Mellitus, Type 1 / therapy*
  • Diabetic Neuropathies / etiology*
  • Diabetic Neuropathies / metabolism
  • Female
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / therapeutic use
  • Male
  • Randomized Controlled Trials as Topic*


  • Hypoglycemic Agents
  • Insulin