Rab GEFs and GAPs

Curr Opin Cell Biol. 2010 Aug;22(4):461-70. doi: 10.1016/j.ceb.2010.04.007. Epub 2010 May 11.


Rabs are GTP-binding proteins with conserved functions in membrane trafficking. They are regulated by a diverse group of structurally unrelated GDP-GTP exchange factors (GEFs), and a family of GTP-hydrolysis activating proteins (GAPs) containing the conserved TBC domain. Recent structural and cell biological studies shed new light on the mechanisms of Rab GEF and GAP action, and the cellular trafficking pathways they act in.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis
  • GTPase-Activating Proteins / chemistry
  • GTPase-Activating Proteins / metabolism*
  • Guanine Nucleotide Exchange Factors / metabolism*
  • Humans
  • Protein Transport
  • Secretory Pathway
  • rab GTP-Binding Proteins / chemistry
  • rab GTP-Binding Proteins / metabolism*


  • GTPase-Activating Proteins
  • Guanine Nucleotide Exchange Factors
  • rab GTP-Binding Proteins