Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome"

Science. 2010 May 14;328(5980):825; author reply 825. doi: 10.1126/science.1183906.

Abstract

Lombardi et al. (Reports, 23 October 2009, p. 585) reported detection of the human gammaretrovirus XMRV in the blood cells of patients with chronic fatigue syndrome (CFS). However, the patient description provided was incomplete. The inclusion of patients from a "CFS outbreak" previously linked with a viral infection, without confirmation in sporadic CFS cases, casts doubt on the role of XMRV in the pathogenesis of CFS.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Cells / virology*
  • Cohort Studies
  • Cytokines / analysis
  • Disease Outbreaks
  • Epidemiologic Research Design
  • Fatigue Syndrome, Chronic / epidemiology
  • Fatigue Syndrome, Chronic / immunology
  • Fatigue Syndrome, Chronic / virology*
  • Gammaretrovirus / isolation & purification*
  • Humans
  • Retroviridae Infections / epidemiology
  • Retroviridae Infections / immunology
  • Retroviridae Infections / virology*
  • Tumor Virus Infections / epidemiology
  • Tumor Virus Infections / immunology
  • Tumor Virus Infections / virology*

Substances

  • Cytokines