Protective immunity to chlamydial genital infection: evidence from animal studies

J Infect Dis. 2010 Jun 15;201 Suppl 2:S168-77. doi: 10.1086/652399.


In all animal models for chlamydial infection, there is strong evidence for immunity to reinfection; however, immunity is only complete (ie, preventing infection) in the short term. In the long term, animals are only partially immune (ie, they can be reinfected, but infections are usually abbreviated and less intense than the primary infection). This review will target the mechanisms responsible for long-term versus short-term immunity and explore the roles of various components of the host response in immunity to chlamydial genital infection.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies, Bacterial / immunology
  • Chlamydia / classification
  • Chlamydia / genetics
  • Chlamydia Infections / drug therapy
  • Chlamydia Infections / immunology*
  • Disease Models, Animal
  • Female
  • Genital Diseases, Female / immunology*
  • Genotype
  • Immunity, Active / drug effects
  • Immunity, Active / immunology
  • Immunity, Cellular / drug effects
  • Immunity, Cellular / immunology
  • Immunity, Innate / drug effects
  • Immunity, Innate / immunology
  • Phenotype


  • Anti-Bacterial Agents
  • Antibodies, Bacterial