Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels

Clin Biochem. 2010 Aug;43(12):1023-5. doi: 10.1016/j.clinbiochem.2010.05.003. Epub 2010 May 12.


Objectives: We have reported that serum glycated albumin (GA) levels are low in obese subjects, smokers and hyperuricemic subjects in whom high sensitive CRP (hs-CRP) is elevated. Because patients with nonalcoholic fatty liver disease with high alanine aminotransferase (ALT) levels are reported to show high levels of hs-CRP, the relationship between serum ALT and serum GA levels was investigated.

Design and methods: This study comprised 196 non-diabetic men without drinking habit.

Results: Compared with the normal ALT group (serum ALT < or =30 U/L; n=158), the high ALT group (serum ALT >30 U/L; n=38) had significantly higher fasting plasma glucose (PG), OGTT 2-h PG and HbA(1C) levels. Meanwhile, serum GA was significantly lower, and hs-CRP was significantly higher in the high ALT group.

Conclusions: The results obtained indicate that serum GA is under a negative control of hs-CRP in subjects with high ALT without drinking habit.

MeSH terms

  • Alanine Transaminase / blood*
  • Blood Glucose / metabolism
  • C-Reactive Protein / metabolism
  • Fatty Liver / blood*
  • Fatty Liver / enzymology
  • Fatty Liver / metabolism*
  • Glycated Hemoglobin / metabolism*
  • Glycated Serum Albumin
  • Glycation End Products, Advanced
  • Humans
  • Hyperuricemia / metabolism
  • Male
  • Middle Aged
  • Obesity / blood
  • Obesity / metabolism
  • Serum Albumin / metabolism*
  • Smoking / blood
  • Smoking / metabolism


  • Blood Glucose
  • Glycated Hemoglobin A
  • Glycation End Products, Advanced
  • Serum Albumin
  • C-Reactive Protein
  • Alanine Transaminase
  • Glycated Serum Albumin