Physical activity and 5-year cognitive decline in the Doetinchem cohort study

Ann Epidemiol. 2010 Jun;20(6):473-9. doi: 10.1016/j.annepidem.2010.03.007.

Abstract

Purpose: It is hypothesized that the intensity of physical activity habits, rather than the time spent on those activities, might mediate cognitive function. This study tested a possible association between changes in the time spent on or the average intensity of weekly physical activities and changes in cognitive function in healthy men and women.

Methods: This longitudinal cohort study with 1,904 healthy men and women (45-75 years of age) assessed physical activity by a questionnaire and cognitive function with a neuropsychological test battery twice with an interval of 5 years.

Results: Multiple linear regression analyses showed that changes in the time spent on physical activities were not associated with changes in cognitive function over a 5-year period. By contrast, changes in average intensity of weekly activities were significantly and positively associated with processing speed (beta = 0.063; p < 0.05).

Conclusions: In this longitudinal cohort study, an increase or smaller decline in average intensity was associated with a smaller age-related decline in processing speed, estimated at 6 years of aging.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging
  • Body Mass Index
  • Cognition Disorders / epidemiology*
  • Cognition*
  • Cohort Studies
  • Female
  • Humans
  • Life Style
  • Linear Models
  • Longitudinal Studies
  • Male
  • Memory
  • Middle Aged
  • Motor Activity*
  • Multivariate Analysis
  • Netherlands / epidemiology
  • Neuropsychological Tests
  • Psychometrics
  • Risk Assessment
  • Risk Factors
  • Statistics, Nonparametric
  • Surveys and Questionnaires
  • Time Factors