5-HT2A receptor gene polymorphisms in Croatian subjects with autistic disorder

Psychiatry Res. 2010 Aug 15;178(3):556-8. doi: 10.1016/j.psychres.2010.04.007. Epub 2010 May 14.


Disturbances in the expression/function of the 5-HT2A receptor are implicated in autism. The association of the 5-HT2A receptor gene with autism was studied in the Croatian population. Distribution frequencies for alleles, genotypes and haplotypes of -1438 A/G and His452Tyr polymorphisms were compared in samples of 103 autistic and 214 control subjects. Significant overrepresentation of the G allele and the GG genotype of the -1438 A/G polymorphism was observed in group of autistic subjects, supporting the possible involvement of the 5-HT2A receptor in the development of autism.

MeSH terms

  • Adolescent
  • Adult
  • Autistic Disorder / epidemiology
  • Autistic Disorder / genetics*
  • Chi-Square Distribution
  • Child
  • Croatia / epidemiology
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic / genetics*
  • Receptor, Serotonin, 5-HT2A / genetics*
  • Young Adult


  • Receptor, Serotonin, 5-HT2A