Unraveling mechanisms of homeostatic synaptic plasticity

Neuron. 2010 May 13;66(3):337-51. doi: 10.1016/j.neuron.2010.04.028.


Homeostatic synaptic plasticity is a negative feedback mechanism that neurons use to offset excessive excitation or inhibition by adjusting their synaptic strengths. Recent findings reveal a complex web of signaling processes involved in this compensatory form of synaptic strength regulation, and in contrast to the popular view of homeostatic plasticity as a slow, global phenomenon, neurons may also rapidly tune the efficacy of individual synapses on demand. Here we review our current understanding of cellular and molecular mechanisms of homeostatic synaptic plasticity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Homeostasis / physiology*
  • Models, Neurological
  • Nerve Net / physiology
  • Neuronal Plasticity / physiology*
  • Neurons / physiology*
  • Synapses / physiology*
  • Synaptic Transmission / physiology