Molecular basis of lysophosphatidic acid-induced NF-κB activation

Cell Signal. 2010 Dec;22(12):1799-803. doi: 10.1016/j.cellsig.2010.05.007. Epub 2010 May 12.

Abstract

PKC, β-arrestin 2, CARMA3, BCL10, MALT1, TRAF6 and MEKK3 are signaling proteins that have a key role in G protein-coupled receptor (GPCR)-mediated activation of nuclear factor-κB (NF-κB) pathway in nonhematopoietic cells in response to lysophosphatidic acid (LPA) stimulation. The PKC, β-arrestin 2, CARMA3-BCL10-MALT1-TRAF6 signalosome, and MEKK3 functions as a link between GPCR signaling and IKK-NF-κB activation. Here we briefly summarize recent progress in the understanding of the molecular and biological functions of these proteins in GPCR-mediated NF-κB activation in nonhematopoietic cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cells, Cultured
  • Fibroblasts / metabolism
  • Forecasting
  • Humans
  • Lysophospholipids / pharmacology*
  • Mice
  • Models, Biological
  • NF-kappa B / metabolism*
  • NIH 3T3 Cells
  • Proteins / metabolism
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction

Substances

  • Lysophospholipids
  • NF-kappa B
  • Proteins
  • Receptors, G-Protein-Coupled
  • lysophosphatidic acid