Eukaryotic translation initiation factor 1 (eIF1), the inspector of good AUG context for translation initiation, has an extremely bad AUG context

J Biosci Bioeng. 2010 Jun;109(6):635-7. doi: 10.1016/j.jbiosc.2009.11.022. Epub 2009 Dec 23.

Abstract

The nucleotide sequence surrounding the translation initiation AUG codon (AUG context) is important for the effective translation initiation. A compilation analysis revealed that all the genes of the eukaryotic translation initiation factor 1, which plays a crucial role in the recognition of the optimal AUG context, ironically have extremely bad AUG contexts.

MeSH terms

  • Animals
  • Base Sequence
  • Codon, Initiator*
  • Eukaryotic Initiation Factors / metabolism*
  • Humans
  • Neoplasm Proteins / metabolism*
  • Nerve Tissue Proteins / metabolism*
  • Protein Biosynthesis*
  • RNA, Messenger / chemistry

Substances

  • Codon, Initiator
  • EIF1 protein, human
  • Eukaryotic Initiation Factors
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • RNA, Messenger