Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration

Stem Cells. 2010 May;28(5):905-15. doi: 10.1002/stem.420.

Abstract

Our understanding of the role of bone marrow (BM)-derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells. Recent studies, however, suggest that the BM contributes a significant proportion of noninflammatory cells to the skin, which are present primarily in the dermis in fibroblast-like morphology and in the epidermis in a keratinocyte phenotype; and the number of these BM-derived cells increases markedly after wounding. More recently, several studies indicate that mesenchymal stem cells derived from the BM could significantly impact wound healing in diabetic and nondiabetic animals, through cell differentiation and the release of paracrine factors, implying a profound therapeutic potential. This review discusses the most recent understanding of the contribution of BM-derived noninflammatory cells to cutaneous homeostasis and wound healing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / physiology*
  • Bone Marrow Transplantation / methods*
  • Bone Marrow Transplantation / trends
  • Dermatologic Surgical Procedures*
  • Humans
  • Regeneration / physiology*
  • Skin / cytology*
  • Skin / injuries
  • Stem Cells / cytology
  • Stem Cells / physiology*
  • Wound Healing / physiology*