Hub promiscuity in protein-protein interaction networks

Int J Mol Sci. 2010 Apr 26;11(4):1930-43. doi: 10.3390/ijms11041930.


Hubs are proteins with a large number of interactions in a protein-protein interaction network. They are the principal agents in the interaction network and affect its function and stability. Their specific recognition of many different protein partners is of great interest from the structural viewpoint. Over the last few years, the structural properties of hubs have been extensively studied. We review the currently known features that are particular to hubs, possibly affecting their binding ability. Specifically, we look at the levels of intrinsic disorder, surface charge and domain distribution in hubs, as compared to non-hubs, along with differences in their functional domains.

Keywords: hubs; interaction networks; promiscuous binding; protein-protein interactions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calmodulin / chemistry
  • Calmodulin / metabolism
  • ELAV Proteins / chemistry
  • ELAV Proteins / metabolism*
  • Humans
  • Protein Interaction Maps
  • Protein Structure, Tertiary


  • Calmodulin
  • ELAV Proteins