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. 2010 Jun 24;53(12):4803-7.
doi: 10.1021/jm100294b.

Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D(3) and Serotonin 5-HT(1A) and 5-HT(2A) Receptors

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Discovery of Bishomo(hetero)arylpiperazines as Novel Multifunctional Ligands Targeting Dopamine D(3) and Serotonin 5-HT(1A) and 5-HT(2A) Receptors

Stefania Butini et al. J Med Chem. .

Abstract

As a continuation of our efforts to develop innovative ligands for D(3), 5-HT(1A), and 5-HT(2A) receptors with low propensity to block hERG channels, we propose a series bishetero(homo)arylpiperazines 5a-m as novel and potent multifunctional ligands characterized by low occupancy at D(2) and 5-HT(2C) receptors.

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