NB-LRR proteins: pairs, pieces, perception, partners, and pathways

Curr Opin Plant Biol. 2010 Aug;13(4):472-7. doi: 10.1016/j.pbi.2010.04.007. Epub 2010 May 17.


In plants, many of the innate immune receptors or disease resistance (R) proteins contain a NB-LRR (Nucleotide-binding site, Leucine-rich repeat) structure. The recent findings regarding NB-LRR signaling are summarized in this article. An emerging theme is that two NB-LRRs can function together to mediate disease resistance against pathogen isolates. Also, recent results delineate the NB-LRR protein fragments that are sufficient to initiate defense signaling. Importantly, distinct fragments of different NB-LRRs are sufficient for function. Finally, we describe the new roles of accessory proteins and downstream host genes in NB-LRR signaling.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Humans
  • Nucleotides / metabolism*
  • Plant Diseases / immunology
  • Plant Proteins / chemistry
  • Plant Proteins / immunology
  • Plant Proteins / metabolism*
  • Repetitive Sequences, Amino Acid*
  • Signal Transduction*


  • Nucleotides
  • Plant Proteins