Exploring the 'RPRL' motif of apelin-13 through molecular simulation and biological evaluation of cyclic peptide analogues

ChemMedChem. 2010 Aug 2;5(8):1247-53. doi: 10.1002/cmdc.201000061.

Authors

N J Maximilian Macaluso¹, Robert C Glen

Affiliation

¹ Unilever Centre for Molecular Sciences Informatics, Department of Chemistry, University of Cambridge, UK.

PMID: 20486151
DOI: 10.1002/cmdc.201000061

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Motifs
Amino Acid Sequence
Binding, Competitive
Hydrogen Bonding
Intercellular Signaling Peptides and Proteins / chemistry*
Intercellular Signaling Peptides and Proteins / pharmacology
Molecular Dynamics Simulation
Protein Structure, Secondary
Receptors, G-Protein-Coupled / chemistry
Receptors, G-Protein-Coupled / metabolism

Substances

Intercellular Signaling Peptides and Proteins
Receptors, G-Protein-Coupled
apelin-13 peptide