Vitamin D and multiple health outcomes in the Harvard cohorts

Mol Nutr Food Res. 2010 Aug;54(8):1114-26. doi: 10.1002/mnfr.200900574.

Abstract

The hypothesis that vitamin D is inversely associated with multiple health outcomes has been studied in the Harvard cohorts, including the Nurses' Health Study I (n=121,700 female nurses aged 37-64 at baseline in 1984), Nurses' Health Study II (n=116,671 female nurses aged 27-44 years at baseline in 1991), Health Professionals Follow-up Study (n=51,529 male health professionals aged 40-75 years at baseline in 1986), and Physicians' Health Study (n=22 071 male physicians aged 40-84 years at baseline in 1982). These studies assessed vitamin D through circulating 25-hydroxyvitamin D, dietary and supplemental intake, predicted 25-hydroxyvitamin D, and vitamin D receptor polymorphisms. This review summarizes studies of vitamin D and various endpoints considered in these cohorts, including risk of cardiovascular disease, hypertension, elevated plasma C-peptide, various cancers, bone fractures, and multiple sclerosis. Based on the multiple observed benefits of vitamin D, this article postulates recommendations for vitamin D intake in the US population for reduced incidence of multiple health outcomes.

Publication types

  • Review

MeSH terms

  • 25-Hydroxyvitamin D 2 / blood
  • Adult
  • Calcifediol / blood
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / prevention & control
  • Cohort Studies
  • Diet
  • Dietary Supplements
  • Female
  • Fractures, Bone / blood
  • Fractures, Bone / epidemiology
  • Fractures, Bone / prevention & control
  • Health Surveys
  • Humans
  • Male
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / prevention & control
  • Neoplasms / blood
  • Neoplasms / epidemiology
  • Neoplasms / prevention & control
  • Nutrition Policy
  • Nutritional Requirements*
  • Polymorphism, Genetic
  • Receptors, Calcitriol / genetics
  • Vitamin D / administration & dosage*
  • Vitamin D / physiology*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / physiopathology*
  • Vitamin D Deficiency / prevention & control*

Substances

  • Receptors, Calcitriol
  • Vitamin D
  • 25-Hydroxyvitamin D 2
  • Calcifediol