Oral mucosal lesions in non oral habit diabetic patients and association of diabetes mellitus with oral precancerous lesions

Diabetes Res Clin Pract. 2010 Sep;89(3):320-6. doi: 10.1016/j.diabres.2010.04.016. Epub 2010 May 20.


Aims: This study was aimed to determine the prevalence of oral mucosal lesions (OML) in patients with diabetes mellitus (DM) and non-diabetic subjects without any oral habits and to investigate the association of DM with oral precancerous lesions.

Methods: This cross-sectional study involved 420 diabetic and 420 non-diabetic control subjects without any oral habits. Detailed oral examination was performed based on international criteria.

Results: A significantly greater proportion of subjects with DM (45%) had one or more OML in comparison to non-diabetics (38.3%). Patients with DM showed a significantly greater prevalence of geographic tongue, denture stomatitis and angular cheilitis than non-diabetics (p<0.05). The results also showed an association between occurrence of one or more OML and metabolic control of diabetic patients (p<0.05). For precancerous lesions, lichen planus was found in two diabetic patients while none of controls had any precancerous lesion (p>0.05).

Conclusions: Prevalence of OML was significantly higher in diabetic patients than non-diabetics and this prevalence was associated with the metabolic control of the patients. However, no association was observed between DM and oral precancerous lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Diabetes Mellitus / pathology
  • Diabetes Mellitus / physiopathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mouth Diseases / complications
  • Mouth Diseases / epidemiology*
  • Mouth Mucosa / pathology*
  • Mouth Neoplasms / epidemiology*
  • Mouth Neoplasms / etiology
  • Precancerous Conditions / epidemiology*
  • Precancerous Conditions / etiology